19. Hyperucicemia may present in patients with
(A) Ankylosing spondylitis
(B) Mycobacterial arthritis
(E) Ganglion cyst
(C) Gout
(D) Lyme arthritis

20. Which of the followings is NOT TRUE for deep fibromatosis (desmoid tumor)? (A) Large, infiltrative mass(B) Frequently recur (C) Frequently metastasize(D) Do not metastasize (E) So-called aggressive fibromatosis

21. The most common form of skeletal malignancy is(A) Chondrosarcoma(B) Osteosarcoma (C) Synovial sarcoma(D) Ewing sarcoma(E) Metastatic tumors

22. Mesothelioma is not found with(A) Asbestos bodies are found in increased numbers in the lungs of patients with mesothelioma (B) The tumor cells show strong immunoreactivity to TTF-1 protein (C) Mesothelioma is usually associated with extensive pleural effusion and direct invasion (D) The affected lung becomes ensheathed by a thick layer of soft, gelat a soft, gelatinous, grayish pink tumor tissue (E) The most common cytogenetic abnormalities is homozygous deletion of chromosome 9p leading to loss ofthe tumor suppressor gene CDKN2A.

23.Which ofthe following descriptions is NOT TRUE for Marfan syndrome?(A) A disorder of connective tissues, manifested principally by changes in the skeleton, eyes and cardiovascular system(B) Marfan syndrome results from an inherited defect in an extracellular glycoprotein called fibrillin-1. (C) Skeletal abnormalities are the most striking () Skeletal abnormalties are the most striking feature of Marfan syndrome (D) The most characteristic eristic ocular change is bilateral subluxation or dislocation of the lens (ectopia lentis) (E) The most common finding of cardiovascular lesions is aortic valve prolapse

24. Glycogen storage disease includes(A) Niemann-Pick disease(B) Gaucher disease (C) Pompe disease(D) Tay-Sachs disease Tay-Sachs disd (E) Mucopolysaccharidoses

25. The chronic disease characterized by dry eyes and dry mouth resulting from immunologically mediated destruction of the lacrimal and salivary glands is(A) Sjögren syndrome(B) Marfan syndrome (C) Systemic lupus erythematosus (D) Rheumatoid arthritis(E) Goodpasture syndrome

26.哪一種病毒性肝炎會造成肝细胞的毛玻璃樣(ground-glass appearance)?(A) hepatitis A (B) hepatitis B (C) hepatitis C (D) hepatitis D (E) hepatitis E.

27. 好發於嬰幼兒期的肝腫瘤為(A) hepatoblastoma(B) hepatocellular carcinoma (C) cholangiocarcinoma(D) focal nodular hyperplasia(E) hepatocellular adenoma

28.胰臟癌最常見的突變發生於下列哪個基因?(A) CDKN2A (B) TP53(C) SMAD4 (D) KRAS (E) BRCA2

29. 最常引起急性膽囊炎的原因為(A)膽結石 (B)細菌性感染(C)病毒性感染 (D)酒精成癮 (E)寄生蟲感染

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