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44.下列何種惡性病最可能以化學治療藥物(chemotherapy)治癒? (A)non-smal cell lung carcinoma (B)colorectal carcinoma (C)seminoma (D)chronic myeloid leukemia

40.66歲男性,自訴以往健康良好。2個月前發現有兩側頸部、腋下與腹股溝淋巴結腫大,經左側淋巴結切片檢 查診斷為angioimmunoblastic T cell lymphoma(AITL),接受全身性化學治療,處方為標準劑量的CHOP (cyclophosphamide, adriamycin, vincristine和prednisolone)。病人於化療2週後返回門診,主訴上腹脹、 排便困難及手指指尖麻木,醫師懷疑可能發生ileus。此副作用最可能由下列何種藥物引起? (A)cyclophosphamide (B)adriamycin (C)prednisolone (D)vincristine

36.標靶治療藥物imatinib是何種蛋白的抑制劑? (A)Bcr-Abl (B)PML-RARa (C)NF-KB (D)EGFRa

38. In the human genome, a variation in a single DNA base pair, such as the substitution of a cytosine ( C ) for a thymine (T), that occurs in more than 1% of the population is known as a __________. They serve as powerful molecular markers in genome-wide association studies (GWAS) to identify genetic predispositions to complex diseases. (A) insertion-deletion mutation (InDel) (B) haplotype block (C) single nucleotide polymorphism (SNP) (D) copy number variant (CNV) (E) short tandem repeat (STR)

40. Which of the following statements about the inheritance of human ABO blood types is correct? (A) It is an example of polygenic inheritance. (B) There are three alleles, IA, IB, and i, for one gene locus. Hence, it does not follow Mendelian Genetics, which only considers two alleles at a single gene locus. (C) ABO blood types refer to glycolipids in the membrane of red blood cells. (D) A couple with blood type AB and blood type O, individually, is not likely to have a child with blood type AB. (E) The blood type AB follows the inheritance pattern of incomplete dominance.

41. Animals and plants can detect and respond to light. Rod cells respond to light by producing action potentials in the optic nerve. In which structure are rod cells located? (A) Iris (B) Pupil (C) Retina (D) Spinal cord (E) Crystalline lens