13. In the blood, free fatty acids are bound to
(A) chylomicron
(B) VLDL
(C) LDL
(D) HDL
(E) albumin

14. Injection of C¹⁴-acetyl-CoA into a rat, the C¹⁴ cannot be found in which fatty acid? (A) palmitic acid (B) stearic acid (C) oleic acid (D) palmitoleic acid (E) linoleic acid

15. Which following enzyme catalyzes the reaction: glucose-1 phosphate + UTP → UDP-glucose + pyrophosphate? (A) UDP-glucose synthetase (B) phosphoglucose uridyltransferase (C) UDP-glucose dehydrogenase (D) UDP-glucose peroxidase (E) UDP-glucose pyrophosphorylase.

16. In glucose metabolism, what enzyme can be directly activated by calcium ion? (A) glucokinase (B) hexokinase (C) glycogen synthase (D) phosphorylase kinase (E) phosphoglucokinase

17. Hydroxylation is important for collagen function. Which factor is required for this posttranslational modification on collagen? (A) acetyl-CoA (B) α-ketoglutarate (C) oxaloacetate (D) NADPH (E) FADH2.

18. Which product is generated by bacteria in terminal ileum and the large intestine? (A) urobilinogen (B) coproporphyrinogen I (C) coproporphyrinogen III (D) uroporphyrinogen II (E) protoporphyrinogen.

複選題19. Which of the following is true about nucleosomes? (A) Nucleosomes are composed of DNA wound around an octameric complex of histone molecules. (B) Nucleosomes contain four major types of histones: H1, H2, H3, and H4. (C) Nucleosomes are the most abundant chromatin proteins. (D) Nonhistone proteins are necessary for the reconstitution of the nucleosome core. (E) All are true.

複選題20. Which of the following statements is correct concerning biosynthesis of purine nucleotides? (A) Glycine, aspartate and glutamate are the nitrogen sources of the purine ring. (B) The major determinant of the rate of de novo purine nucleotide biosynthesis is the concentration of5-phosphoribosyl 1-pyrophosphate. (C) von Gierke disease reflects a defect in hypoxanthine-guanine phosphoribosyl transferase, an enzyme of purine salvage. (D) AMP and GMP also inhibit hypoxanthine-guanine phosphoribosyl transferase, which converts hypoxanthine and guanine to AMP and GMP. (E) All are true.

21. Which of the following RNA species is NOT directly involved in protein synthesis? (A) mRNAs (B) tRNAs (C) snRNAs (D) rRNAs (E) None of them.

22. Which of the following nomenclature names is right for the unsaturated fatty acid below? [Image of a fatty acid molecule] (A) ω5, C20:4 (B) ω6, C20:5 (C) ω5, C19:4 (D) ω6, C19:5 (E) ω6, C20:4

23. Which one of the following molecules in Glycolysis donates a phosphate group to ADP to produce ATP? (A) glucose-6-phosphate (B) phosphoenolpyruvate (C) fructose-6-phosphate (D) fructose-1,6-bisphosphate (E) pyruvate

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