18. Which of the following compounds would cross a biological membrane most readily by nonmediated diffusion?
(A) water
(B) acetone
(C) hexane
(D) acetic acid
(E) methanol

19. The quaternary structure of human hemoglobin is best described as a (A) dimer of two myoglobin dimers. (B) tetramer of identical subunits. (C) tetramer of four different subunits. (D) tetramer of two different subunits.

20. The steady state assumption in enzyme kinetics: (A) insures that the product of an enzymatic reaction will always be formed (B) explains why enzymes are effective catalysts (C) states that the formation of ES is equal to its breakdown (D) is based upon the fact that the maximum velocity of an enzyme is very high (E) none of the above

21. In the following enzyme reaction scheme, what sort of multi-enzyme kinetics are shown? (A) ordered substrate binding with random product release (B) ordered substrate binding with ordered product release (C) random substrate binding with ordered product release (D) random substrate binding with random product release (E) ping-pong mechanism

22. A peptide was found to have a molecular mass of about 650 and upon hydrolysis produced Ala, Cys, Lys, Phe, and Val in a 1:1:1:1:1 ratio. The peptide upon treatment with Sanger's reagent produced DNP-Cys and exposure to carboxypeptidase produced valine. Chymotrypsin treatment of the peptide produced a dipeptide that contained sulfur and has a UV absorbance, and a tripeptide. Exposure of the peptide to trypsin produced a dipeptide and a tripeptide. Deduce the sequence of the peptide. (A) Val-Ala-Lys-Phe-Cys (B) Cys-Lys-Phe-Ala-Val (C) Cys-Ala-Lys-Phe-Val (D) Cys-Phe-Lys-Ala-Val (E) Val-Phe-Lys-Ala-Cys

23. What type of inhibitor would give the results seen in the following plot? (A) competitive inhibitor (B) mixed inhibitor (C) noncompetitive inhibitor (D) uncompetitive inhibitor (E) none of the above

24. The two amino acids most often found in a polypeptide α helix are proline and (A) alanine (B) glycine (C) serine (D) histidine

25. What happens when the GTPase activity of a G protein βγ subunit is blocked? (A) the α subunit associates with the βγ subunit, not they subuunit (B) GTP hydrolysis to GMP (C) binding to α GPCR occurs with very high affinity (D) adenylyl cyclase remains active (E) none of the above

101.有機溶劑中毒預防規則第三種有機溶劑或其混存物，容許消費量(g)為作業場所氣積(m3)乘以下列何者?(A)2/5(B)1/5(C)3/2(D)1/15

102.下列何者是有機溶劑中毒預防規則規定有機溶劑容許消費量之功用?(A)作為評斷是否可不受限制設置各種預防設施之判斷(B)容許使用量之判斷(C)了解勞工之最大暴露量(D)容許浪費量之判斷

103.有關甲醇之敘述，下列何者錯誤?(A)對視神經具毒性(B)變性酒精成分之一(C)可直接飲用(D)俗稱木精

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