19. In mammals, RNA polymerase I catalyzes the transcription of:
(A) mRNA
(B) miRNAs
(C) rRNA
(D) tRNA
(E) All are right

20. Oncologists employ 5-fluorouracil (5-FU) in chemotherapy. Which one of the following 5-FU derivates can inhibit thymidylate synthase? (A) 5-FUTP (B) 5-FdUTP (C) 5-FUDP (D) 5-FUMP (E) 5-FdUMP

21. Which kinds of RNA processing described below is through methylation and cleavage? (A)rRNA (B)tRNA (C) siRNA (D) mRNA (E) IncRNA

22. Which description of the difference between prokaryotic and eukaryotic RNA polymerase is WRONG? (A) Prokaryotic cells contain only one RNA polymerase. (B) The size of eukaryotic RNA polymerase is around 500 kDa. (C) Prokaryotic RNA polymerase synthesizes polycistronic RNA. (D) The eukaryotic RNA polymerase contains 10-20 subunits. (E) None of the above are wrong.

23. Which mechanism described below is NOT tRNA processing? (A) RNase P cut (B) RNase D cut (C) Splicing (D) CCA addition (E) None of the above all are wrong

24. Which subunit described below is NOT a core enzyme component of bacterial RNA polymerase? (A)A (B)B (C)β'(D)σ (E)γ

25. Which description of the difference between DNA and RNA synthesis is WRONG? (A) Both DNA and RNA synthesis have highly active and efficient proofreading functions. (B) Deoxyribonucleotides are used in DNA synthesis. (C) RNA polymerase does not need a primer to initiate the synthesis of RNA. (D) U replaces T as the complementary base for A in RNA. (E) Only portions of the genome are transcribed into RNA, whereas the entire genome must be copied once and only once during DNA replication.

26. Which of the following enzyme is the rate limiting step for cholesterol synthesis? (A) HMG-CoA synthase (B) HMG-CoA reductase (C) Squalene synthetase (D) Squalene monooxygenase (E) Cholesterol 7o-hydroxylase (CYP7AI)

27. Which of the following apolipoprotein is acquired from HDL by nascent VLDL to serve as the enzyme co-factor for lipoprotein lipase ? (A) Apolipoprotein A (B) Apolipoprotein B-100 (C) Apolipoprotein B-48 (D) Apolipoprotein C (E) Apolipoprotein D

28. Which of the following play key role in regulating cholesterol metabolism by both uptake of cholesterol ester in liver and efflux of cholesterol in tissue? (A) ATP binding cassette transporter A1 (ABCA1). (B) ATP binding cassette transporter G1 (ABCG1). (C) Lipoprotein Lipase anchored by heparan sulfate proteoglycans. (D) Class B scavenger receptor B1 (SR-B1). (E) Lecithin cholesterol acyI transferase (LCAT).

29. Which of the following does NOT result in increased hormone sensitive lipase activity? (A) Adenylate cyclase activated by epinephrine. (B) Phosphorylated of perilipin. (C) Activation of cAMP-dependent protein kinase. (D) Activation of lipase phosphatase. (E) Administer phosphodiesterase inhibitor.

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