27. _____is   NOT   involved in intron removal and the processing of mRNA precursors into mRNA.
(A) U2 snRNA
(B) U3 snRNA
(C) U4 snRNA
(D) U5 snRNA
(E) U6 snRNA 

28. A mutation is any change in the base sequence of the DNA. Which one of the following descriptions about mutations is   WRONG  ? (A) An adenosine replaced by a cytidine is a "transversion" mutation (B) An adenosine replaced by a guanosine is a "transition" mutation (C) A nonsense mutation results in a different amino acid being inserted in the protein (D) Silent mutation means a change at the DNA level that does not result in any change of amino acid in the encoded protein. (E) All are right.

29. In leucine zipper motifs, leucine residues occur at every (A) 4th position (B) 5th position (C) 6th position (D) 7th position (E) 8th position.

30. Oncologists employ 5-fluorouracil (5-FU) in chemotherapy. Which one of the following 5-FU derivates can inhibit thymidylate synthase? (A) 5-FUTP (B) 5-FdUTP (C) 5-FUDP (D) 5-FUMP (E) 5-FdUMP

31. Transamination requires which of the cofactors (A) Mg, (B) B12, (C) Fe, (D) PLP, (E) NAD

32. S-adenosylmethionine is involved in the transfer of (A) CH3, (B) CH2OH, (C) CHO, (D) COOH, (E) NH2

33. Which of the following methods was NOT invented to increase the throughput of DNA deep sequencing? (A) Pyrosequencing, (B) Sequencing by ligation, (C) Sequencing by synthesis, (D) Sanger sequencing, (E) semiconductor sequencing

34. The corresponding alpha-keto acid after aspartate deamination is (A) fumarate, (B) oxaloacetate, (C) pyruvate, (D) alpha-ketoglutarate, (E) citrate

35. One turn of the citric acid cycle produces (A) 2 NADH, 2 FADH2, 2 ATP. (B) 3 NADH, 1 FADH2, 1 ATP. (C) 1 NADH, 3 FADH2, 2 ATP. (D) 3 NADH, 2 FADH2, 1 ATP. (E) 2 NADH, 2 FADH2, 1 ATP.

36. The anaerobic conversion of 1 mol of glucose to 2 mol of lactate by fermentation is accompanied by a net gain of: (A) 2 mol of ATP+ 1 mol of NADH (B) 2 mol of ATP + 2 mol of NADH (C) 2 mol of NADH (D) 1 mol of NADH (E) 2 mol of ATP

37. Which of the following enzyme does not take part in the TCA cycle? (A) Citrate synthase (B) Malate dehydrogenase (C) Aconitase (D) Pyruvate dehydrogenase (E) Succinate dehydrogenase

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