18. Which of the following can inhibit HMG-CoA reductase?
(A) bile acid
(B) cholesterol
(C) mevalonate
(D) simvastatin
(E) all of above

19. Which of the following amino acid residues in principle can NOT participate in acid-base catalysis? (A) serine (B) aspartatic acid (C) cysteine (D) phenylalanine (E) glutamic acid

20. Kinetic analysis revealed that the presence of enzyme inhibitor "X" increases the Km but does NOT affect Vmax of an enzymatic reaction. Based on this finding, we can conclude that the inhibitor "X" should be a(an) _______. (A) competitive inhibitor (B) uncompetitive inhibitor (C) mixed inhibitor (D) allosteric inhibitor (E) noncompetitive inhibitor

21. "Catalytic antibodies" mainly accelerate the rate of a chemical reaction by ______. (A) acid base catalysis (B) stabilization of transition state (C) covalent catalysis (D) metal ion catalysis (E) alteration of the reaction pathway

22. For a human enzyme, the highest reaction rate is usually observed at which of the following temperature? (A) 10°C (B) 20°C (C) 30°C (D) 40°C (E) 50°C

23. Which following factor can activate phosphorylase kinase? (A) selenium (B)(C) (D)(E)

24. Which following enzyme product is required for bilirubin metabolism? (A) hexokinase (B) phosphofrutokinase-1 (C) UDP-glucose dehydrogenase (D) glucose 6-phosphate dehydrogenase (E) phosphofructokinase-2

25. When human cells synthesize cysteine amino acid, there are two amino acids needed for the biosynthesis. What are these two amino acids? (A) methionine and alanine (B) methionine and serine (C) glutamine and glycine (D) serine and glycine (E) arginine and aspartate

26. Which following factor is an important reactant for human asparagine synthetase to generate asparagine? (A) (B) arginine (C) glutamate (D) lysine (E) glutamine

27. _____is   NOT   involved in intron removal and the processing of mRNA precursors into mRNA.(A) U2 snRNA (B) U3 snRNA (C) U4 snRNA (D) U5 snRNA (E) U6 snRNA 

28. A mutation is any change in the base sequence of the DNA. Which one of the following descriptions about mutations is   WRONG  ? (A) An adenosine replaced by a cytidine is a "transversion" mutation (B) An adenosine replaced by a guanosine is a "transition" mutation (C) A nonsense mutation results in a different amino acid being inserted in the protein (D) Silent mutation means a change at the DNA level that does not result in any change of amino acid in the encoded protein. (E) All are right.

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