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44.下列何種惡性病最可能以化學治療藥物(chemotherapy)治癒? (A)non-smal cell lung carcinoma (B)colorectal carcinoma (C)seminoma (D)chronic myeloid leukemia

40.66歲男性,自訴以往健康良好。2個月前發現有兩側頸部、腋下與腹股溝淋巴結腫大,經左側淋巴結切片檢 查診斷為angioimmunoblastic T cell lymphoma(AITL),接受全身性化學治療,處方為標準劑量的CHOP (cyclophosphamide, adriamycin, vincristine和prednisolone)。病人於化療2週後返回門診,主訴上腹脹、 排便困難及手指指尖麻木,醫師懷疑可能發生ileus。此副作用最可能由下列何種藥物引起? (A)cyclophosphamide (B)adriamycin (C)prednisolone (D)vincristine

42.關於grade IV astrocytoma(glioblastoma)的敘述,何者錯誤? (A)此疾病預後不佳,平均存活期小於2年 (B)首次治療以手術,接續併用化學治療(temozolomide)及放射治療為主要治療方式 (C)O6-methylguanine-DNA methyltransferase(MGMT)有表現的腫瘤,對於temozolomide的治療較有療效 (D)bevacizumab可用於復發後的病人,此藥物可以減少腫瘤周邊的水腫,也可延長progression-free survival

28. A man taking multiple medications develops drug toxicity. Laboratory analysis reveals impaired Phase I metabolism. Which of the following reactions is most likely deficient in this patient? (A) Hydroxylation by cytochrome P450 (B) Glucuronidation by UDP-glucuronyltransferase (C) Sulfation by sulfotransferase (D) Glutathione conjugation by glutathione S-transferase (E) Acetylation by N-acetyltransferase

29. A researcher incubates hepatocytes with 15NH4Cl and observes that 15N appears first in glutamate, then subsequently in aspartate. Which of the following best explains this sequential labeling? (A) 15NH4+ → glutamine (by glutamine synthetase) → glutamate → aspartate (by transamination) (B)  15NH4+→ glutamate (by glutamate dehydrogenase) → aspartate (by transamination with oxaloacetate) (C) 15NH4+→ carbamoyl phosphate (by CPS I) → glutamate → aspartate (via urea cycle intermediates) (D)  15NH4+ → glutamate (by glutamate dehydrogenase using succinate) → aspartate (by transamination with fumarate) (E)  15NH4+→ glutamate (by glutamine synthetase) → aspartate (by reductive amination of oxaloacetate)