4. An allosteric interaction between a ligand and a protein is one in which:
(A) binding of a molecule to a binding site affects binding of additional molecules to the same site.
(B) binding of a molecule to a binding site affects binding properties of another site on the protein.
(C) binding of the ligand to the protein is covalent.
(D) multiple molecules of the same ligand can bind to the same binding site.
(E) two different ligands can bind to the same binding site.

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